A scoping review of the measurement and analysis of frailty in randomised controlled trials.

ABSTRACT:

Background

Frailty is of increasing interest in trials, either as a target of intervention, as an outcome or as a potential treatment modifier. However, frailty measurement is often highly variable. This scoping review assessed how frailty is quantified in randomised controlled trials (RCTs), in what context and for what purposes.

Methods

We searched five electronic databases for RCTs in which frailty was measured among trial participants. We extracted data on intervention type, the frailty measure used and the purpose for which frailty was assessed. We then compared these data according to reasons for frailty assessment.

Results

We identified 415 RCTs assessing frailty across a range of interventions. Frailty was used to define the target population (166 trials), as

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11581818 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature