A switch in the pathway of TRPC3-mediated calcium influx into brain pericytes contributes to capillary spasms after subarachnoid hemorrhage.

ABSTRACT: Calcium influx and subsequent elevation of the intracellular calcium concentration ([Ca²⁺]_i) induce contractions of brain pericytes and capillary spasms following subarachnoid hemorrhage. This calcium influx is exerted through cation channels. However, the specific calcium influx pathways in brain pericytes after subarachnoid hemorrhage remain unknown. Transient receptor potential canonical 3 (TRPC3) is the most abundant cation channel potentially involved in calcium influx into brain pericytes and is involved in calcium influx into other cell types either via store-operated calcium entry (SOCE) or receptor-operated calcium entry (ROCE). Therefore, we hypothesized that TRPC3 is associated with [Ca²⁺]_i elevation in brain pericytes, potentially med

SUBMITTER: Li Y 

PROVIDER: S-EPMC11581875 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature