The Role of the Glymphatic System in Perioperative Neurocognitive Disorders.

ABSTRACT:

Background

The glymphatic system plays a crucial role in clearing metabolic waste from the central nervous system and is most active during sleep. Patients with obstructive sleep apnea (OSA) have a dysfunctional glymphatic system that correlates with disease severity. In addition, these patients have worse outcomes after surgery. The status of the glymphatic system during the perioperative period is unclear and can be examined with magnetic resonance imaging (MRI)-based diffusion tensor imaging (DTI). This study assessed perioperative glymphatic system changes in OSA surgical patients and possible relationships with perioperative neurocognitive disorders.

Methods

DTI data from 13 OSA patients having laparoscopic abdominal surgery with general anesthesia were acquired and ana

SUBMITTER: Roy B 

PROVIDER: S-EPMC11582080 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature