Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.

ABSTRACT:

Objective

To establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T.

Materials and methods

Echo times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.

Results

Simulations, phantom and in vivo measurements s

SUBMITTER: Tkotz K 

PROVIDER: S-EPMC11582128 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature