LY354740, an agonist of glutamatergic metabotropic receptor mGlu_2/3 increases the cytochrome P450 2D (CYP2D) activity in the frontal cortical area of rat brain.

ABSTRACT:

Background

Our previous studies indicated that changes in the functioning of the brain glutamatergic system involving the NMDA receptor may affect cytochrome P450 2D (CYP2D) in the brain. Since CYP2D may contribute to the metabolism of neurotransmitters and neurosteroids engaged in the pathology and pharmacology of neuropsychiatric diseases, in the present work we have investigated the effect of compound LY354740, an agonist of glutamatergic metabotropic receptor mGlu_2/3, on brain and liver CYP2D.

Methods

The activity (high performance liquid chromatography with fluorescence detection) and protein levels (Western blotting) of CYP2D were measured in the microsomes from the liver and different brain areas of male Wistar rats after 5 day-treatment with LY354740 (10 m

SUBMITTER: Bromek E 

PROVIDER: S-EPMC11582139 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature