Towards assessing and improving the reliability of ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI of cortical bone: In silico and ex vivo study.

ABSTRACT:

Objective

To assess and improve the reliability of the ultrashort echo time quantitative magnetization transfer (UTE-qMT) modeling of the cortical bone.

Materials and methods

Simulation-based digital phantoms were created that mimic the UTE-qMT properties of cortical bones. A wide range of SNR from 25 to 200 was simulated by adding different levels of noise to the synthesized MT-weighted images to assess the effect of SNR on UTE-qMT fitting results. Tensor-based denoising algorithm was applied to improve the fitting results. These results from digital phantom studies were validated via ex vivo rat leg bone scans.

Results

The selection of initial points for nonlinear fitting and the number of data points tested for qMT analysis have minimal effect on the fitting result

SUBMITTER: Shin SH 

PROVIDER: S-EPMC11582156 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature