Obesity-related drug transporter expression alterations in human liver and kidneys.

ABSTRACT:

Background

Pathophysiological changes associated with obesity might impact various drug pharmacokinetics (PK) parameters. The liver and kidneys are the primary organs involved in drug clearance, and the function of hepatic and renal transporters is critical to efficient drug elimination (or reabsorption). Considering the impact of an increased BMI on the drug's PK is crucial in directing dosing decisions. Given the critical role of transporters in drug biodisposition, this study investigated how overweight and obesity affect the gene expression of renal and hepatic drug transporters.

Methods

Human liver and kidney samples were collected post-mortem from 32 to 28 individuals, respectively, which were divided into the control group (lean subjects; 18.5 ≤ BMI < 25 kg/m²

SUBMITTER: Kosicka-Noworzyn K 

PROVIDER: S-EPMC11582170 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature