Activation of 5-HT₇ receptors in the mouse dentate gyrus does not affect theta-burst-induced plasticity at the perforant path synapse.

ABSTRACT:

Background

The study examined the effects of 5-HT₇ receptor activation on GABAergic transmission within the dentate gyrus and plasticity at the glutamatergic perforant path input.

Methods

Immunofluorescence imaging was performed using transverse hippocampal slices from transgenic mice expressing green fluorescent protein (GFP) under the Htr7 promoter. This was followed by whole-cell patch clamp electrophysiological recordings assessing the effects of pharmacologically activating 5-HT₇ receptors on spontaneous inhibitory postsynaptic currents recorded from dentate granule cells and hilar mossy cells-two glutamatergic neuron types present in the dentate gyrus. Extracellular recordings of field excitatory postsynaptic potentials were then performed to asse

SUBMITTER: Siwiec M 

PROVIDER: S-EPMC11582198 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature