Comparative analysis of positron emitters for theranostic applications based on small bioconjugates highlighting ⁴³Sc, ⁶¹Cu and ⁴⁵Ti.

ABSTRACT:

Background

Targeted radionuclide therapy with ¹⁷⁷Lu-labelled small conjugates is expanding rapidly, and its success is linked to appropriate patient selection. Companion diagnostic conjugates are usually labelled with ⁶⁸Ga, offering good imaging up to ≈2 h post-injection. However, the optimal tumor-to-background ratio is often reached later. This study examined promising positron-emitting radiometals with half-lives between 3 h and 24 h and β⁺ intensity (I_β+) ≥ 15% and compared them to ⁶⁸Ga. The radiometals included: ⁴³Sc, ⁴⁴Sc, ⁴⁵Ti, ⁵⁵Co, ⁶¹Cu, ⁶⁴Cu, ⁶⁶Ga, ^85mY, ⁸⁶Y, ⁹⁰Nb, ¹³²La, ¹⁵⁰Tb and ¹

SUBMITTER: Hindie E 

PROVIDER: S-EPMC11582248 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature