Numerical simulation method for the assessment of the effect of molar activity on the pharmacokinetics of radioligands in small animals.

ABSTRACT:

Background

It is well recognized that the molar activity of a radioligand is an important pharmacokinetic parameter, especially in positron emission tomography (PET) of small animals. Occupation of a significant number of binding sites by radioligand molecules results in low radioligand accumulation in a target region (mass effect). Nevertheless, small-animal PET studies have often been performed without consideration of the molar activity or molar dose of radioligands. A simulation study would therefore help to assess the importance of the mass effect in small-animal PET. Here, we introduce a new compartmental model-based numerical method, which runs on commonly used spreadsheet software, to simulate the effect of molar activity or molar dose on the pharmacokinetics of radioligand

SUBMITTER: Kikuchi T 

PROVIDER: S-EPMC11582259 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature