Roles of cathepsin S expression levels on the prognosis and tumour microenvironment in clear cell renal cell carcinoma.

ABSTRACT:

Background

Increasing evidence suggests a link between the enzyme cathepsin S (CTSS) and tumour development. However, the potential involvement and molecular functions of CTSS in clear cell renal cell carcinoma (ccRCC) remain unclear.

Methods

We downloaded original data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases and integrated them using R. Kaplan-Meier plots of integrated expression scores were used to analyse survival outcomes. Additionally, we investigated mRNA expression, clinicopathological features, immune infiltrates, and single-cell sequencing analysis of CTSS in ccRCC. In vitro experiments were conducted with qRT-PCR and IHC staining.

Results

CTSS transcriptomic and proteomic levels were higher in ccRCC than in para-cancer

SUBMITTER: Wang X 

PROVIDER: S-EPMC11582264 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature