On the physiological and structural contributors to the overall balance of excitation and inhibition in local cortical networks.

ABSTRACT: Overall balance of excitation and inhibition in cortical networks is central to their functionality and normal operation. Such orchestrated co-evolution of excitation and inhibition is established through convoluted local interactions between neurons, which are organized by specific network connectivity structures and are dynamically controlled by modulating synaptic activities. Therefore, identifying how such structural and physiological factors contribute to establishment of overall balance of excitation and inhibition is crucial in understanding the homeostatic plasticity mechanisms that regulate the balance. We use biologically plausible mathematical models to extensively study the effects of multiple key factors on overall balance of a network. We characterize a network's baseline bal

SUBMITTER: Shirani F 

PROVIDER: S-EPMC11582336 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature