Neighborhood Stressors and Epigenetic Age Acceleration Among Older Americans.

ABSTRACT:

Objectives

Exposure to stressful neighborhood environments is a well-established risk factor for health deterioration and premature death. However, the biological underpinnings are not fully understood. Epigenetic aging may function as a key molecular pathway to adverse health outcomes among residents of high-stress neighborhoods. This study examines the associations between neighborhood social stressors (socioeconomic deprivation, observed and perceived disorder, and low social cohesion) and epigenetic age (DunedinPACE and Principal component adjusted [PC] PCHorvath, PCHannum, PCPhenoAge, PCGrimAge). Further, we identify subpopulations most vulnerable to neighborhood stressors.

Methods

Respondent data are from the 2016 Health and Retirement Study (HRS) DNA methylation subsa

SUBMITTER: Choi EY 

PROVIDER: S-EPMC11582398 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature