Deciphering the conformational changes induced by high-risk nsSNPs in β-lactoglobulin.

ABSTRACT: Whey protein from bovine milk is highly valued in the food and pharmaceutical industries because of its high protein content and abundance of essential amino acids. The relationship between whey protein and the β-lactoglobulin (BLG) gene has been extensively discussed because BLG is the most abundant whey protein, making up approximately 50 % of the total whey protein in bovine milk. In recent years, researchers have been interested in this gene because of its critical role in healthy milk production, and any genetic polymorphism in this gene may deteriorate the milk quality. In the current study, we identified several deleterious and damaging non-synonymous single nucleotide polymorphisms (nsSNPs) in BLG and analyzed their destabilizing effects using different computational algorithms. Cu

SUBMITTER: Sahoo S 

PROVIDER: S-EPMC11582417 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature