Causal relationship between cancer and immune cell traits: A two-sample mendelian randomization study.

ABSTRACT:

Background

Observational studies provide evidence of correlations between cancer and the immune system. Previous research has established associations between immune traits and the propensity for developing certain cancers. However, a systematic exploration of these connections remains largely uncharted. Therefore, further investigation is needed to examine the causal association between cancer and immune cell traits using Mendelian randomization (MR) approach.

Methods

We identified genetic instruments for breast cancer (BC), lung cancer (LC), endometrial cancer (EC), ovarian cancer (OC), prostate cancer (PC), and their subtype cancers to investigate their potential causal impact on immune traits. Data on cancer and immune cell traits were obtained from the IEU Open GWAS pro

SUBMITTER: Qiu Z 

PROVIDER: S-EPMC11582454 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature