Iodinated Cyanoacrylate-Based Novel Liquid Embolic Compositions with Inherent Radiopacity for Endovascular Embolization.

ABSTRACT: Endovascular embolization is a promising therapeutic approach broadening its application area due to its minimal invasiveness and short operation time, wherein lesional blood vessels are occluded with liquid embolic agents under X-ray imaging guidance. Histoacryl and its composition with Lipiodol are one of the most widely used liquid embolic agents, however, Histoacryl has critical limitations, such as lack of innate X-ray visibility and strong adhesion to microcatheter. In this study, three different iodinated cyanoacrylates are newly synthesized as alternatives to Histoacryl and employed to develop liquid embolic compositions. Among them, 4-iodobutyl 2-cyanoacrylate (IBCA) is most preferable with high iodine content (730 mgI mL^-1) and fast polymerization. The IBCA-based embol

SUBMITTER: Jeon SI 

PROVIDER: S-EPMC11582500 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature