Remolding the tumor microenvironment by bacteria augments adoptive T cell therapy in advanced-stage solid tumors.

ABSTRACT: The intricate tumor microenvironment presents formidable obstacles to the efficacy of adoptive T cell therapy in the management of solid tumors by limiting the infiltration and inducing exhaustion of the transferred T cells. Here, we developed a bacterial-based adjuvant approach that augments the efficacy of adoptive T-cell therapy for solid tumor treatment. Our study reveals that intratumor injection of E. coli MG1655 normalizes tumor vasculatures and reprograms tumor-associated macrophages into M1 phenotype that produce abundant CCL5, together facilitating tumor infiltration of adoptively transferred T cells. The depletion of tumor-associated macrophages or CCL5 neutralization in vivo leads to the significantly decreased solid tumor infiltration of adoptive T cells in the presence of bac

SUBMITTER: Zhu C 

PROVIDER: S-EPMC11582571 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature