Plasmodium berghei liver stage parasites exploit host GABARAP proteins for TFEB activation.

ABSTRACT: Plasmodium, the causative agent of malaria, infects hepatocytes prior to establishing a symptomatic blood stage infection. During this liver stage development, parasites reside in a parasitophorous vacuole (PV), whose membrane acts as the critical interface between the parasite and the host cell. It is well-established that host cell autophagy-related processes significantly impact the development of Plasmodium liver stages. Expression of genes related to autophagy and lysosomal biogenesis is orchestrated by transcription factor EB (TFEB). In this study, we explored the activation of host cell TFEB in Plasmodium berghei-infected cells during the liver stage of the parasite. Our results unveiled a critical role of proteins belonging to the Gamma-aminobutyric acid receptor-associated protein

SUBMITTER: Schmuckli-Maurer J 

PROVIDER: S-EPMC11582615 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature