Personalised antimicrobial susceptibility testing with clinical prediction modelling informs appropriate antibiotic use.

ABSTRACT: Antimicrobial susceptibility testing is a key weapon against antimicrobial resistance. Diagnostic microbiology laboratories use one-size-fits-all testing approaches that are often imprecise, inefficient, and inequitable. Here, we report a personalised approach that adapts laboratory testing for urinary tract infection to maximise the number of appropriate treatment options for each patient. We develop and assess susceptibility prediction models for 12 antibiotics on real-world healthcare data using an individual-level simulation study. When combined with decision thresholds that prioritise selection of World Health Organisation Access category antibiotics (those least likely to induce antimicrobial resistance), the personalised approach delivers more susceptible results (results that encou

SUBMITTER: Howard A 

PROVIDER: S-EPMC11582675 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature