A biological rhythm in the hypothalamic system links sleep-wake cycles with feeding-fasting cycles.

ABSTRACT: The hypothalamus senses the appetite-regulating hormones and also coordinates the metabolic function in alignment with the circadian rhythm. This alignment is essential to maintain the physiological conditions that prevent clinically important comorbidities, such as obesity or type-2 diabetes. However, a complete model of the hypothalamus that relates food intake with circadian rhythms and appetite hormones has not yet been developed. In this work, we present a computational model that accurately allows interpreting neural activity in terms of hormone regulation and sleep-wake cycles. We used a conductance-based model, which consists of a system of four differential equations that considers the ionotropic and metabotropic receptors, and the input currents from homeostatic hormones. We prop

SUBMITTER: Tamayo-Molina YS 

PROVIDER: S-EPMC11582708 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature