Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for <i>In Vitro</i> and <i>In Cellulo</i> Assays.

ABSTRACT: The need for the development of specific and robust methodologies to elucidate the intricate pathological mechanisms of neurodegenerative diseases and discover effective treatments for prevention and remediation is evident. Alzheimer's disease, in particular, has become more prevalent as the global population has aged. β-Secretase, the β-site amyloid precursor protein cleaving enzyme (BACE1), is the protease that produces the β-amyloid peptide, which is considered one of the driving factors of Alzheimer's disease and an important target for treatment development. However, an understanding of its activity, modulation, and regulation is far from complete. This is in large part due to the complex nature of following its activity. Beyond the common requirements for all biosensors (ease of prep

SUBMITTER: Tosat-Bitrian C 

PROVIDER: S-EPMC11583121 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature