Recruiting the Immune System against Pathogenic Bacteria Using High-Affinity Chimeric Tags.

ABSTRACT: The immune system plays a critical role in protecting the host against pathogens. However, mechanisms for evading the immune system have evolved in pathogens, altering their surface proteins or causing the expression of enzymes that interfere with the immune response. These strategies cause pathogens to escape detection and destruction by the immune system, thereby inducing severe infections. Thus, there is a critical need to develop new chemical tools to recruit the immune system against evading pathogens. Here, we describe a novel strategy for targeting pathogens, by labeling them with a chimeric agent that comprises a peptide bacterial binder, conjugated to an immune-protein tag that is recognizable by the complement system, thereby recruiting the immune system against the targeted path

SUBMITTER: Belo Y 

PROVIDER: S-EPMC11583208 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature