Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer's disease.

ABSTRACT: Alzheimer's Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible symptoms with no cure; therefore, disaggregation of these tau fibrils could be targeted as a therapeutic approach to AD. Here we have developed a fungal natural product library to screen for secondary metabolites that have bioactive potential towards AD tau. Our initial screenings indicate that penicillic acid demonstrates anti-aggregation activity towards tau, while further in vitro experiments reveal that penicillic acid directly inhibits tau by disaggregating fibrils. Although penicillic acid possesses blood-brain barrier penetrability properties that are computationally pred

SUBMITTER: Shyong J 

PROVIDER: S-EPMC11583217 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature