Investigation of the whitening activity of ginsenosides from Panax notoginseng and optimization of the dosage form.

ABSTRACT:

Background

Ginsenoside, as an active ingredient in traditional Chinese medicine, has been widely used for skin whitening for several years. Recent research has found that Panax notoginseng has a higher content of ginsenosides compared with the Panax ginseng. Those ginsenosides have promising potential to be developed as skin whitening agents.

Methods

We selected five dammarane ginsenosides isolated from P. notoginseng and their mixtures to investigate the skin lightning activity. Zebrafish embryo model was used for initial screening of the whitening activity. Subsequently, the whitening effect of components was examined and compared via testing the inhibition of melanin and activity of tyrosinase in B16 cells treated with these components. Molecular docking was also applied

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11583341 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature