Characterization of Apathy-Like Behaviors in Mouse Models of Down Syndrome.

ABSTRACT:

Background

Apathy is a state of decreased interest, lack of initiative, reduced goal-directed activity and blunted emotional responses. Apathy is one of the most common neuropsychiatric symptoms (NPS) in patients with Alzheimer's disease (AD) and is also relatively omnipresent in individuals with Down syndrome (DS). Little is known about the apathy-like behaviors in rodent models of AD and DS.

Objective

This study aimed to characterize apathy-like behaviors with aging in two established DS mouse models: Ts65Dn and Dp16.

Methods

A battery of behavioral tests including nestlet shredding, marble burying, nest building, and burrowing were performed to examine apathy-like behaviors. Individual z-scores for each mouse for each test, and a composite z-score of apathy-like be

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11583345 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature