Disrupted White Matter Topology Organization in Preschool Children with Tetralogy of Fallot.

ABSTRACT:

Background

Cognitive impairment is the most common long-term complication in children with congenital heart disease (CHD) and is closely related to the brain network. However, little is known about the impact of CHD on brain network organization. This study aims to investigate brain structural network properties that may underpin cognitive deficits observed in children with Tetralogy of Fallot (TOF).

Methods

In this prospective study, 29 preschool-aged children diagnosed with TOF and 19 without CHD (non-CHD) were enrolled. Participants underwent diffusion tensor imaging (DTI) scans alongside cognitive assessment using the Chinese version of the Wechsler Preschool and Primary Scale of Intelligence-fourth edition (WPPSI-IV). We constructed a brain structural network based on D

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11583477 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature