Characterization of oral microbiota of children with hand, foot, and mouth disease caused by enterovirus A 71.

ABSTRACT:

Background

The association between alterations in the oral microbiome and hand, foot, and mouth disease (HFMD) has been observed in previous studies. Our study, therefore, aimed to identify the structural changes in the oral microbiota and biomarkers in children with HFMD caused by enterovirus A 71 (EV-A71).

Methods

Children diagnosed with EV-A71 HFMD and healthy children recruited from April 2021 to September 2023 were included in the present study, and were categorized into EV-A71 and control groups, respectively. Oral swabs were collected and microbiota information was obtained using 16 S rRNA gene sequencing technology. Alpha-diversity and partial least squares discriminant analyses were conducted to compare microbial diversity, richness, and similarity between the two g

SUBMITTER: Shen N 

PROVIDER: S-EPMC11583527 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature