Longitudinal decline in DAT binding in Parkinson's disease: connections with sleep disturbances.

ABSTRACT:

Background

The nigrostriatal dopamine (DA) system plays a critical role in regulating the sleep-wake state. The relationship between baseline striatal DA transporter (DAT) specific binding ratios (SBR) and rapid eye movement sleep behavior disorder (RBD) has been established. This study aimed to investigate the association between the progression of striatal DA dysfunction and sleep disturbances, including excessive daytime sleepiness (EDS) and probable RBD (pRBD), in patients with Parkinson's disease (PD).

Methods

Data were obtained from the Parkinson's Progression Markers Initiative (PPMI). Six hundred twenty-one newly diagnosed PD patients and followed up for 4 years were included in this longitudinal study. EDS and pRBD were defined using the Epworth Sleepiness Scale (ES

SUBMITTER: Ren J 

PROVIDER: S-EPMC11583529 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature