Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation.

ABSTRACT:

Background

MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged as a key modulator of inflammation, but its role in obesity-induced senescence remains unexplored. This study investigates the involvement of miR-146a in high-fat diet (HFD)-induced hypothalamic senescence and in protective effects of elocalcitol (Elo), a non-hypercalcemic, fluorinated vitamin D analog on HFD-induced senescence.

Results

Wild-type (WT) HFD-fed mice exhibited increased body weight, impaired locomotor activity, and cognitive decline compared to low-fat diet (LFD) controls. In the brain, HFD induced senescence markers (p16, p21), β-galactosidase activity (β-gal) of microglia, and increased expression of senescence associated secre

SUBMITTER: Chithanathan K 

PROVIDER: S-EPMC11583547 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature