Roles of the lncRNAs MEG3, PVT1 and H19 tagSNPs in gastric cancer susceptibility.

ABSTRACT:

Background

Improper expression of long noncoding RNAs (lncRNAs) can cause various cancers. Single nucleotide polymorphisms (SNPs) affect the expression and function of several key lncRNAs. We assessed the associations of MEG3, PVT1, and H19 lncRNA polymorphisms with susceptibility to gastric cancer (GC).

Methods

In Ardabil (a high-risk area in North‒West Iran), 795 blood samples were collected from 396 cases and 399 controls. The control subjects were randomly selected from individuals receiving regular physical examinations in this hospital with no self-reported cancer history and were frequency-matched to the case group by sex and 5-year age intervals. All the samples were genotyped via the Infinium HTS platform, which was subsequently followed by rigorous data quality con

SUBMITTER: Abdi E 

PROVIDER: S-EPMC11583566 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature