Combined impact of prediabetes and hepatic steatosis on cardiometabolic outcomes in young adults.

ABSTRACT:

Objectives

This study aimed to investigate the impact of hepatic steatosis on cardiometabolic outcomes in young adults with prediabetes.

Methods

A nationwide cohort study was conducted with 896,585 young adults under 40 years old without diabetes or previous history of cardiovascular disease. Hepatic steatosis was identified using a fatty liver index of ≥ 60. The outcomes of this study were incident diabetes (DM) and composite major adverse cardiovascular events (MACE), including myocardial infarction, stroke, or cardiovascular death.

Results

During a median follow-up of 11.8 years, 27,437 (3.1%) incident DM cases and 6,584 (0.7%) MACE cases were recorded. Young adults with prediabetes had a significantly higher risk of incident DM (hazard ratio [HR]: 2.81; 95% confid

SUBMITTER: Choi W 

PROVIDER: S-EPMC11583572 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature