<i>B. vulgatus</i> ameliorates high-fat diet-induced obesity through modulating intestinal serotonin synthesis and lipid absorption in mice.

ABSTRACT: The consumption of high-fat diets (HFD) and an imbalance in gut microbiome are linked to obesity. However, the intricate connection between them and the underlying mechanisms involved in lipid digestion and absorption remain largely unclear. This study shows that after 12 weeks of HFD feeding, C57BL/6J mice exhibit two distinct metabolic phenotypes with significant differences in gut microbiota composition. The LOW and LOW FMT group mice with increased Bacteroides are protected from obesity, insulin resistance, and lipid accumulation. Supplementation with B. vulgatus or cholic acid (CA) alleviates HFD-induced obesity and metabolic dysfunction. This is due to the accumulation of lipid droplets and the retention of chyle particles in jejunal epithelial cells, which reduces chyl

SUBMITTER: Wen X 

PROVIDER: S-EPMC11583587 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature