Rotavirus rewires host cell metabolic pathways toward glutamine catabolism for effective virus infection.

ABSTRACT: Rotavirus (RV) accounts for 19.11% of global diarrheal deaths. Though GAVI assisted vaccine introduction has curtailed RV induced mortality, factors like RV strain diversity, differential infantile gut microbiome, malnutrition, interference from maternal antibodies and other administered vaccines, etc. often compromise vaccine efficacy. Herein emerges the need of antivirals which can be administered adjunct to vaccination to curb the socio-economic burden stemming from frequent RV infection. Cognisance of pathogen-perturbed host cellular physiology has revolutionized translational research and aided precision-based therapy, particularly for viruses, with no metabolic machinery of their own. To date there has been limited exploration of the host cellular metabolome in context of RV infectio

SUBMITTER: Mitra S 

PROVIDER: S-EPMC11583611 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature