Nanotechnology-driven therapies for neurodegenerative diseases: a comprehensive review.

ABSTRACT: Neurological diseases, characterized by neuroinflammation and neurodegeneration, impose a significant global burden, contributing to substantial morbidity, disability and mortality. A common feature of these disorders, including stroke, traumatic brain injury and Alzheimer's disease, is the impairment of the blood-brain barrier (BBB), a critical structure for maintaining brain homeostasis. The compromised BBB in neurodegenerative conditions poses a significant challenge for effective treatment, as it allows harmful substances to accumulate in the brain. Nanomedicine offers a promising approach to overcoming this barrier, with nanoparticles (NPs) engineered to deliver therapeutic agents directly to affected brain regions. This review explores the classification and design of NPs, divided in

SUBMITTER: Lopez-Espinosa J 

PROVIDER: S-EPMC11583628 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature