Prospective study on the association between 36 human blood cell traits and pan-cancer outcomes: a mendelian randomization analysis.

ABSTRACT:

Background

Research on the link between blood cell traits and cancer risk has gained significant attention. Traditional epidemiological and cell biology studies, have identified correlations between blood traits and cancer risks. These findings are important as they suggest potential risk factors and biological mechanisms. However, these studies often can't confirm causality, pointing to the need for further investigation to understand these relationships better.

Methods

Mendelian randomization (MR), utilizing single-nucleotide polymorphisms as instrumental variables, was employed to investigate blood cell trait causal effects on cancer risk. Thirty-six blood cell traits were analyzed, and their impact on 28 major cancer outcomes was assessed using data from the FinnGen coho

SUBMITTER: Liang J 

PROVIDER: S-EPMC11583664 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature