8-Bromo-cAMP attenuates human airway epithelial barrier disruption caused by titanium dioxide fine and nanoparticles.

ABSTRACT: Titanium dioxide fine particles (TiO₂-FPs) and nanoparticles (TiO₂-NPs) are the most widely used whitening pigments worldwide. Inhalation of TiO₂-FPs and TiO₂-NPs can be harmful as it triggers toxicity in the airway epithelial cells. The airway epithelium serves as the respiratory system's first line of defense in which airway epithelial cells are significant targets of inhaled pathogens and environmental particles. Our group previously found that TiO₂-NPs lead to a disrupted barrier in the polarized airway epithelial cells. However, the effect of TiO₂-FPs on the respiratory epithelial barrier has not been examined closely. In this study, we aimed to compare the effects of TiO₂-FPs and TiO₂-NPs on the s

SUBMITTER: Lee CE 

PROVIDER: S-EPMC11583697 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature