Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.

ABSTRACT:

Background

Hyperoside (quercetin-3-O-β-D-galactopyranoside) is a flavonol glycoside compound derived from plants in the Hypericum and Crataegus genera that reportedly exhibits an array of anti-inflammatory, antioxidant, and antitumor properties such that it has been used to treat various diseases. Whether it can serve as an effective treatment for chronic myeloid leukemia (CML) cells, however, has yet to be established. The present study was thus devised to assess the therapeutic effects of hyperoside on CML cells and to clarify the underlying mechanism of action.

Methods

Cellular viability, proliferative activity, migration, and apoptotic death were respectively analyzed through CCK-8, EDU, transwell, and flow cytometry assays. RNA-seq and bioinformatics approaches were fur

SUBMITTER: Wei J 

PROVIDER: S-EPMC11583796 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature