Comprehensive phylogenomic analysis of Zika virus: Insights into its origin, past evolutionary dynamics, and global spread.

ABSTRACT:

Background

Zika virus (ZIKV), a Flaviviridae family member, has been linked to severe neurological disorders. Despite detailed studies on recent outbreaks, the early evolutionary history of ZIKV remains partially unclear. This study elucidates ZIKV origin and evolutionary dynamics, focusing on recombination events, early lineage diversification, and virus spread across continents.

Methods

We assessed recombination using multiple methods. We conducted Bayesian phylogenetic analyses to understand the evolutionary relationships and timing of key diversification events. Model selection was carried out to determine the most appropriate evolutionary model for our dataset.

Results

Our phylogenies revealed recent recombination between Singaporean and African lineages, indicat

SUBMITTER: Zadra N 

PROVIDER: S-EPMC11583807 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature