Intra-striatal dopaminergic inter-subject covariance in social drinkers and non-treatment-seeking alcohol use disorder participants.

ABSTRACT: One of the neurobiological correlates of alcohol use disorder (AUD) is the disruption of striatal dopaminergic function. Although regional differences in dopamine (DA) tone/function have been well studied, interregional relationships (represented as inter-subject covariance) have not been investigated and may offer a novel avenue for understanding DA tone. Positron emission tomography (PET) data with [¹¹C]raclopride in 22 social drinking controls and 17 AUD participants were used to generate group-level striatal covariance (partial Pearson correlation) networks, which were compared edgewise as well as on global network metrics and community structure. An exploratory analysis examined the impact of tobacco cigarette use status. Striatal covariance was validated in an independent

SUBMITTER: Chumin EJ 

PROVIDER: S-EPMC11583815 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature