Causal Inference Over a Subpopulation: The Effect of Malaria Vaccine in Women During Pregnancy.

ABSTRACT: Preventing malaria during pregnancy is of critical importance, yet there are no approved malaria vaccines for pregnant women due to lack of efficacy results within this population. Conducting a randomized trial in pregnant women throughout the entire duration of pregnancy is impractical. Instead, a randomized trial was conducted among women of childbearing potential (WOCBP), and some participants became pregnant during the 2-year study. We explore a statistical method for estimating vaccine effect within the target subpopulation-women who can naturally become pregnant, namely, women who can become pregnant under a placebo condition-within the causal inference framework. Two vaccine effect estimators are employed to effectively utilize baseline characteristics and account for the fact that

SUBMITTER: Hu Z 

PROVIDER: S-EPMC11583954 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature