Blind But Alive - Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish.

ABSTRACT:

Purpose

Vision is the predominant sense in most animal species. Loss of vision can be caused by a multitude of factors resulting in anatomic as well as behavioral changes. In mice and zebrafish, atoh7 mutants are completely blind as they fail to generate retinal ganglion cells (RGCs) during development. In contrast to mice, raising blind zebrafish to adulthood is challenging and this important model is currently missing in the field. Here, we report the phenotype of homozygous mutant adult zebrafish atoh7 mutants that have been raised using adjusted feeding and holding conditions.

Methods

The phenotype of adult mutants was characterized using classical histology and immunohistochemistry as well as optical coherence tomography. In addition, the optokinetic response was charac

SUBMITTER: Hammer J 

PROVIDER: S-EPMC11583992 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature