Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition.

ABSTRACT: The neocortex is a complex neurobiological system with many interacting regions. How these regions work together to subserve flexible behavior and cognition has become increasingly amenable to rigorous research. Here, I review recent experimental and theoretical work on the modus operandi of a multiregional cortex. These studies revealed several general principles for the neocortical interareal connectivity, low-dimensional macroscopic gradients of biological properties across cortical areas, and a hierarchy of timescales for information processing. Theoretical work suggests testable predictions regarding differential excitation and inhibition along feedforward and feedback pathways in the cortical hierarchy. Furthermore, modeling of distributed working memory and simple decision-making ha

SUBMITTER: Wang XJ 

PROVIDER: S-EPMC11583996 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature