Discovery of nostatin A, an azole-containing proteusin with prominent cytostatic and pro-apoptotic activity.

ABSTRACT: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are intriguing compounds with potential pharmacological applications. While many RiPPs are known as antimicrobial agents, a limited number of RiPPs with anti-proliferative effects in cancer cells are available. Here we report the discovery of nostatin A (NosA), a highly modified RiPP belonging among nitrile hydratase-like leader peptide RiPPs (proteusins), isolated from a terrestrial cyanobacterium Nostoc sp. Its structure was established based on the core peptide sequence encoded in the biosynthetic gene cluster recovered from the producing strain and subsequent detailed nuclear magnetic resonance and high-resolution mass spectrometry analyses. NosA, composed of a 30 amino-acid peptide core, features a uniqu

SUBMITTER: Delawska K 

PROVIDER: S-EPMC11583998 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature