Multifunctional hydrogel electronics for closed-loop antiepileptic treatment.

ABSTRACT: Closed-loop strategies offer advanced therapeutic potential through intelligent disease management. Here, we develop a hydrogel-based, single-component, organic electronic device for closed-loop neurotherapy. Fabricated out of conductive hydrogels, the device consists of a flexible array of microneedle electrodes, each of which can be individually addressed to perform electrical recording and control chemical release with sophisticated spatiotemporal control, thus pioneering a smart antiseizure therapeutic system by combining electrical and pharmacological interventions. The recorded neural signal acts as the trigger for a voltage-driven drug release in detected pathological conditions predicted by real-time electrophysiology analysis. When implanted into epileptic animals, the device enab

SUBMITTER: Qu J 

PROVIDER: S-EPMC11584000 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature