Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis.

ABSTRACT: We present a versatile nickel-electrocatalytic deaminative cross-coupling platform for the efficient construction of C(sp³)-C(sp³) and C(sp³)-C(sp²) bonds from readily available alkyl bistriflimides. This methodology involves the assembly of two leaving groups on alkyl amines to form alkyl bistriflimides, followed by their effective coupling with a wide range of alkyl halides, alkyl pseudohalides, aryl halides, and alkenyl halides under electrochemical reductive conditions. Moreover, the successful application of electrochemical reductive relay cross-coupling and transition metal-free cross-electrophile coupling further demonstrates the versatility of alkyl bistriflimides as valuable building blocks in organic synthesis. Combined control experime

SUBMITTER: Tao X 

PROVIDER: S-EPMC11584002 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature