An electrodiffusive network model with multicompartmental neurons and synaptic connections.

ABSTRACT: Most computational models of neurons assume constant ion concentrations, disregarding the effects of changing ion concentrations on neuronal activity. Among the models that do incorporate ion concentration dynamics, simplifications are often made that sacrifice biophysical consistency, such as neglecting the effects of ionic diffusion on electrical potentials or the effects of electric drift on ion concentrations. A subset of models with ion concentration dynamics, often referred to as electrodiffusive models, account for ion concentration dynamics in a way that ensures a biophysical consistent relationship between ion concentrations, electric charge, and electrical potentials. These models include compartmental single-cell models, geometrically explicit models, and domain-type models, but

SUBMITTER: Sætra MJ 

PROVIDER: S-EPMC11584141 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature