Panax notoginseng saponins promotes angiogenesis after cerebral ischemia-reperfusion injury.

ABSTRACT:

Background

Ischemic stroke is a devastating disease that can result in permanent disability and death, and angiogenesis plays a critical role in the recovery and survival of patients and animal models of ischemic stroke. Panax notoginseng has been used as a key herb in the treatment of stroke diseases due to its effect in promoting blood circulation and removing blood stasis. However, the role of Panax notoginseng saponins, in promoting angiogenesis is unclear.

Purpose

This study is aimed to investigate the effect of Xueshuantong (XST) injection, composed of Panax notoginseng saponins in post-stroke revascularization.

Method

In the present study, a middle cerebral artery occlusion/reperfusion model was established in Sprague-Dawley rats, with XST and the positive drug

SUBMITTER: Xiao H 

PROVIDER: S-EPMC11584196 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature