Oxygenation Severity Categories and Long-Term Quality of Life among Children who Survive Septic Shock.

ABSTRACT: Objectives  This study aimed to test whether early oxygenation failure severity categories (absent/mild/moderate/severe) were associated with health-related quality of life (HRQL) deterioration among children who survived sepsis-related acute respiratory failure. Methods  We performed a secondary analysis of a study of community-acquired pediatric septic shock, Life After Pediatric Sepsis Evaluation. The primary outcome was an adjusted decline in HRQL ≥ 25% below baseline as assessed 3 months following admission. Logistic regression models were built to test the association of early oxygenation failure including covariates of age and nonrespiratory Pediatric Logistic Organ Dysfunction-2 score. Secondarily, we tested if there was an adjusted decline in HRQL at 6 and 12 months

SUBMITTER: Kohne JG 

PROVIDER: S-EPMC11584271 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature