Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations.

ABSTRACT: Pulmonary arteriovenous malformations (PAVMs) universally develop in patients with single ventricle congenital heart disease. Single ventricle PAVMs have been recognized for over 50 years but remain poorly understood. To improve our understanding, we developed a surgical rat model of Glenn circulation and characterized PAVM physiology over multiple time points. We performed a left thoracotomy and end-to-end anastomosis of the left superior vena cava to the left pulmonary artery (unilateral Glenn), or sham surgical control. To assess PAVM physiology, we quantified intrapulmonary shunting using two independent methods (bubble echocardiography and fluorescent microsphere injection). Additionally, we performed arterial blood gas measurements to assess oxygenation and plethysmography to assess

SUBMITTER: Wan TC 

PROVIDER: S-EPMC11584281 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature