The impact of vaccines for diarrhoea on antibiotic use among children in five low-resource settings: a comparative simulation study.

ABSTRACT:

Background

Vaccines for diarrhoea could have the ancillary benefit of preventing antibiotic use. We aimed to quantify and compare the expected impact of enteric vaccines on antibiotic use via Monte Carlo simulations.

Methods

We analysed data from a longitudinal birth cohort, which enrolled children from 2009 to 2012 from Bangladesh, India, Nepal, Pakistan, and Tanzania. We used Monte Carlo simulations to estimate hypothetical vaccine impact in nine vaccination scenarios (including six single vaccines and three combination vaccines) on antibiotic- treated diarrhoea, overall antibiotic courses, and antibiotic exposures to bystander pathogens. For each vaccine scenario, we randomly selected target pathogen-specific diarrhoea episodes to be prevented according to the specified v

SUBMITTER: Rogawski McQuade ET 

PROVIDER: S-EPMC11584313 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature